CUENCA, Patricia and RAMIREZ, Vanessa. Aberraciones cromosómicas en trabajadoras expuestas a plaguicidas. Rev. biol. trop [online]. , vol, n.3, pp. ABERRACIONES. CROMOSÓMICAS. Dra. Laura Santana Díaz Médico Genetista. Morfología y estructura de los cromosomas humanos. Cariotipo Constitución. PDF | On Jan 1, , Fernado N. Dulout and others published Análisis de aberraciones cromosómicas en anafase-telofase de la mitosis. I. Acción clastogénica.

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The cytogenetic assay as a measure of genetic instability induced by genotoxic agents. There are several factors able to modify the number of micronuclei aberarciones in a given cell, among them are age, gender, vitamins, medical treatments, daily exposure to genotoxic agents, etc.

The cytogenetic assay for the detection of micronuclei CBMN: The micronuclei scoring is performed on binucleated cells and the starting sample may vary, although most studies are performed on peripheral blood lymphocytes. The micronuclei assay is considered a practical, universally validated and technically feasible aberracions which is useful to evaluate the genetic instability induced by genotoxic agents.

El recuento aberracionees MN se debe realizar sobre 1. Al contrario, varias publicaciones han detectado diferencias entre grupos de fumadores y no fumadores: The cytokinesis-block micronucleus technique: Mutat Res ; Kirsch-Volders M, Fenech M. Hainaut P, Pfeifer GP. Mutability of p53 hotspot codons to benzo a pyrene diol epoxide BPDE and the frequency of p53 mutations in nontumorous human lung.

Conferencia: Impacto de las Aberraciones Cromosómicas en la Salud. ~ Ciber-Genética

Cancer Res ; Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences. Chem Res Toxicol ; High susceptibility to lung cancer analyzed in terms of combined genotypes of PIA1 and Mu-class glutathione S-transferase genes. Jpn J Cancer Res ; The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes.


Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. The in vitro micronucleus technique.

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Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ Mol Mutagen ; Micronuclei in lymphocytes of young patients under antileukemic therapy. Sex chromosome loss, micronuclei, sister chromatid exchange and aging: Fenech M, Crott JW.

Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus aberraciiones.

Micronucleus formation in peripheral-blood lymphocytes from smokers and absrraciones influence of alcohol- and tea-drinking habits. Int J Cancer ; Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants vitamin E, vitamin C, beta-carotene and red ginseng.

Cancer Lett ; Ginseng reduces the micronuclei yield in lymphocytes after irradiation. Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment.

Micronuclei in cytokinesis-blocked lymphocytes as an index of occupational exposure to alkylating cytostatic drugs.

Micronucleus monitoring of a floriculturist population from western Liguria, Italy. Micronuclei frequencies in hospital workers occupationally exposed to low levels of ionizing radiation: Cytogenetic biomonitoring of Spanish greenhouse workers exposed to pesticides: Micronucleus induction in gill cells of green-lipped mussels Perna viridis exposed to mixtures of polycyclic aromatic hydrocarbons and chlorinated pesticides.


Environ Toxicol Chem ; Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1, subjects in an Italian population: Contribution of sex, age, and lifestyle.

Conferencia: Impacto de las Aberraciones Cromosómicas en la Salud. ~ Ciber-Genética

Factors contributing to chromosome damage in lymphocytes of cigarette smokers. Influence of smoking habit on the frequency of abfrraciones in human lymphocytes by the cytokinesis block method. Cell division, chromosomal damage and micronucleus formation in peripheral lymphocytes of healthy donors: The micronucleus assay in human lymphocytes: Effect of smoking habit on the frequency of micronuclei in human lymphocytes: Clastogenic effect for cigarette smoking but not areca quid chewing as measured by micronuclei in exfoliated buccal mucosal cells.

Chromosomal instability in amniocytes from fetuses of mothers who smoke. Importance of detecting numerical versus structural chromosome aberrations.

The position of the in vitro micronucleus test within the battery of screening for genotoxic potential determination and the regulatory guidelines. Micronuclei and chromatid buds are the result of related genotoxic events.

A protocol for the in vitro micronucleus test. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity. Norppa H, Falck GC. What do human micronuclei contain? Zalacain 1L.